Research Investigator, Translational Science

  • Location:Cambridge,MA
  • Department:Translational
  • Type:Full Time
  • Min. Experience:Mid Level


Surface Oncology is working to advance next-generation approaches to cancer immunotherapy based on proprietary insights into novel immunotherapy targets and emerging areas of biology. We are seeking a creative and motivated immunohistochemistry/immunofluorescence specialist to be part of our growing company. This is a hands-on lab position in a highly dynamic, team-oriented environment. Qualified candidates should be hard-working, highly motivated, and possess a proactive attitude and strong desire to discover novel biology and potential new therapeutics. Candidates should also fit in well with the collaborative, rigorous and entrepreneurial spirit of our company culture.



  • Work closely with members of the research and translational teams to develop and execute novel tissue-based biomarker assays in support of clinical program translational activities.
  • Operational day-to-day maintenance of molecular pathology laboratory activities with respect to equipment, supplies, and reagents, with oversight from translational pathologist.
  • Coordinate and organize the collection and analysis of cell line and tissue samples internally and with external partners. 
  • Review scientific literature, as well as investigate and develop new tissue-based approaches, reagents, and techniques for project advancement.
  • Support CRO vendor relationships, external assay qualification and validation as well as clinical data analysis arising from outsourced activities as appropriate.
  • Prepare technical reports, summaries, protocols and quantitative analyses and communicate results regularly at team meetings to ultimately drive decision-making
  • Maintain organized lab records and documentation.



  • BA/BS or MS degree in life sciences or related field with 5-10 or more years’ experience in industry or academia. Experience in immuno-oncology or cancer biology is preferred.
  • Demonstrated expertise in tissue-based assays including single and multiplex immunohistochemistry (IHC), immunofluorescence (IF), and in situ hybridization (ISH, FISH) techniques; in-depth technical knowledge and hands-on experience in slide-based assay development including optimization and troubleshooting of novel antibodies and nucleic acid probes.
  • General histology/histopathology skills including tissue handling, embedding, processing, sectioning (FFPE and frozen tissues and cell lines), tissue and cell culture, and routine light microscopy.
  • Experience with automated staining, whole slide scanning, and quantitative image analysis using automated software.
  • Efficient time management, excellent organizational and communication skills, problem solving skills, and a high degree of flexibility.
  • Prior experience with one or more of the following techniques: multiparameter flow cytometry (FACS), MSD, Luminex, ELISA, Western Blotting, is a plus.