Research Investigator, Translational Science

  • Location:Cambridge,MA
  • Department:Translational
  • Type:Full Time
  • Min. Experience:Mid Level

JOB SUMMARY:

Surface Oncology is working to advance next-generation approaches to cancer immunotherapy based on proprietary insights into novel immunotherapy targets and emerging areas of biology. We are seeking a creative and motivated immunohistochemistry/immunofluorescence specialist to be part of our growing company. This is a hands-on lab position in a highly dynamic, team-oriented environment. Qualified candidates should be hard-working, highly motivated, and possess a proactive attitude and strong desire to discover novel biology and potential new therapeutics. Candidates should also fit in well with the collaborative, rigorous and entrepreneurial spirit of our company culture.

 

RESPONSIBILITIES:

  • Work closely with members of the research and translational teams to develop and execute novel tissue-based biomarker assays in support of clinical program translational activities.
  • Operational day-to-day maintenance of molecular pathology laboratory activities with respect to equipment, supplies, and reagents, with oversight from translational pathologist.
  • Coordinate and organize the collection and analysis of cell line and tissue samples internally and with external partners. 
  • Review scientific literature, as well as investigate and develop new tissue-based approaches, reagents, and techniques for project advancement.
  • Support CRO vendor relationships, external assay qualification and validation as well as clinical data analysis arising from outsourced activities as appropriate.
  • Prepare technical reports, summaries, protocols and quantitative analyses and communicate results regularly at team meetings to ultimately drive decision-making
  • Maintain organized lab records and documentation.

 

EDUCATION AND EXPERIENCE: 

  • BA/BS or MS degree in life sciences or related field with 5-10 or more years’ experience in industry or academia. Experience in immuno-oncology or cancer biology is preferred.
  • Demonstrated expertise in tissue-based assays including single and multiplex immunohistochemistry (IHC), immunofluorescence (IF), and in situ hybridization (ISH, FISH) techniques; in-depth technical knowledge and hands-on experience in slide-based assay development including optimization and troubleshooting of novel antibodies and nucleic acid probes.
  • General histology/histopathology skills including tissue handling, embedding, processing, sectioning (FFPE and frozen tissues and cell lines), tissue and cell culture, and routine light microscopy.
  • Experience with automated staining, whole slide scanning, and quantitative image analysis using automated software.
  • Efficient time management, excellent organizational and communication skills, problem solving skills, and a high degree of flexibility.
  • Prior experience with one or more of the following techniques: multiparameter flow cytometry (FACS), MSD, Luminex, ELISA, Western Blotting, is a plus.