Principal Scientist, Translational Science

  • Location:Cambridge, MA
  • Department:Research and Development
  • Type:Full Time
  • Min. Experience:Senior Manager/Supervisor


Covid- 19 Mandatory Vaccination Requirement

Throughout the pandemic, we’ve done all that we can to keep our employees safe, and the employees coming in have been careful to take precautions to reduce the risk of bringing Covid into our work environment. As we reopen our office, we’re mindful that the pandemic is not yet over, and young children are not yet vaccinated. We are committed to continuing to protect our team and keep our office safe.  Vaccination has proven to be the best thing you can do to protect yourself, your family, your colleagues and your community. Since we are striving for a 100% vaccinated workplace (including employees, contractors, vendors and guests), all NEW HIRES will be required to be fully vaccinated, and to present proof of their Covid-19 vaccination to our HR team as part of our on-boarding process.



Surface Oncology is working to advance next-generation approaches to cancer immunotherapy based on proprietary insights into novel immunotherapy targets and emerging areas of biology. We are seeking an individual with experience in clinical biomarker development, implementation, and interpretation in the field of immuno-oncology to be part of our growing company. This is not only a hands-on lab position, but qualified candidates will also work cross-functionally with team members and stakeholders across the organization.  Successful candidates should be hard-working, highly motivated, and possess a proactive attitude with strong communication skills. Candidates should also fit in well with the collaborative spirit of our company culture.



  • Lead the development and implementation of translational biomarker strategies and activities to inform patient selection/stratification, pharmacodynamics, and mechanism of action for Surface Oncology clinical pipeline programs.
  • Provide oversight of the development, validation, and execution of clinical biomarker assays with external CROs and actively manage vendor relationships.
  • Serve as the translational science lead representative to cross-functional Program Development Teams (PDT) and help drive integrated program development plans.
  • Lead and drive external collaborations and sponsored research agreements that enable our translational efforts to help inform and advance our clinical programs.
  • Drive clinical trial biomarker sample testing and data analysis in close collaboration with the clinical development operations and data sciences group.



  • PhD, MD or MD/PhD with 5+ years industry experience or master’s degree and 10 years of scientific experience developing biomarker strategies in a clinical development setting.
  • Research and translational scientist with a varied scientific skillset and experience across a broad number of analytical platforms and in vitro and in vivo assays including demonstrated expertise with molecular biology techniques, multiparameter FACS, multiplex immunoassay platforms, as well as genomic profiling and gene expression analysis.
  • Experience with clinical biomarker assay development, validation, and clinical trial implementation. Knowledge and translational biomarker development experience in oncology and/or immuno-oncology is highly desirable.
  • Experience working with clinical samples and biomarker data.
  • Excellent communication & organizational skills with a strong ability to convey complex scientific and business issues to a broad range of stakeholders.